One-pot two-step synthesis of 2-aryl benzimidazole N-oxides using microwave heating as a tool

POLITANO, FABRIZIO; GRAN-MAGANO, ANA K.; LEADBEATER, NICHOLAS E.

MOLECULES

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Año: 2019 vol. 24

1420-3049

methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification.